Wait, what? Did I just reference “iOS 6 compatibility”?
Yes, there are a few minor issues related to API changes from Apple. We can’t go into detail about them yet due to Apple’s non-disclosure agreement by which all Apple developers are bound. However, you will want to pay attention to PhoneGap/Cordova 2.1 release, and upgrade accordingly if your application is impacted. Most existing apps won’t be affected, but a small number may encounter an issue or two. Be sure to test your apps on the iOS 6 beta to make sure they are ready. There are workarounds to these issues without having to upgrade to PhoneGap 2.1, but all new apps targeting iOS 6 will definitely want to use PhoneGap 2.1 or newer.
You can check out the Apache Cordova JIRA bug tracker for the 2.1 release to see a bit more of what is involved in the upcoming release.